Biomécanique cardiovasculaire


How do cells respond to mechanical stimulation ?

C.L.M. Gouget - Y. Hwang - A. I. Barakat

Why?

Fig. 1: Cells in undisturbed flow (up) or in disturbed flow (dow)

Cells are constantly subjected to mechanical forces and these forces regulate cell structure and function. Thus, in arteries, cells in regions of disturbed flow have an abnormal behavior, and vascular disease tends to appear in these regions, marked in red in Fig. 1.

How ?

Fig. 2: The cytoskeleton, the mechanical backbone of the cell, plays a key role in transmitting force within cells.

We are studying force transmission in a model cytoskeleton (Fig. 2) consisting of network of beams that are either randomly oriented or directionnally aligned (Fig. 3)

Results

Fig. 3: Force transmission dynamics in aligned and random networks

Our results (Fig. 3) provide insight into the different mechanisms at stake in healthy and diseased arterial regions.

Publications

Gouget CL, Hwang Y, Barakat AI. Model of cellular mechanotransduction via actin stress fibers. Biomech Model Mechanobiol. 2015 Jun 17:1-14. preprint
Hwang Y, Gouget CL, Barakat AI. Mechanisms of cytoskeleton-mediated mechanical signal transmission in cells. Commun Integr Biol. 2012 Nov 1;5(6):538-42. preprint